International
| Alzheimer\’s Disease Diagnostics Innovation and Translation to Clinical Practice in Central Europe | |
| – | |
| Program: | Horizon Europe |
| Project leader: | doc. MVDr. Žilka Norbert, DrSc. |
| Duration: | 1.1.2023 – 31.12.2026 |
| PROGRESS – Predisponujúce k chorobám alebo podporujúce odolnosť? Dekódovanie biológie systémov, markerov a determinantov bodu zlomu stresu | |
| Disease-predisposing or resilience-promoting? Decoding the systems biology and behavioural predictors and determinants of the tipping point of stress | |
| Program: | ERANET |
| Project leader: | prof. Ing. Jurišica Igor, DrSc. |
| Duration: | 1.12.2023 – 30.11.2026 |
| Non-globular proteins in the era of Machine Learning | |
| – | |
| Program: | COST |
| Project leader: | Ing. Cehlár Ondrej, PhD. |
| Duration: | 1.10.2022 – 31.10.2026 |
| Multi-MeMo – Krátkodobý a dlhodobý mechanizmus multimodálnej intervencie pre prevenciu demencie | |
| Shorter- and longer-term mechanisms of multimodal interventions to prevent dementia | |
| Program: | Horizon Europe |
| Project leader: | MUDr. Novák Petr, PhD. |
| Duration: | 1.4.2023 – 30.6.2026 |
| Double-edged sword of Parkinson\’s disease: the study of extracellular vesicles as a mediator of pathology spreading and uniquesource of early diagnostics data | |
| – | |
| Program: | ICGEB |
| Project leader: | MUDr. RNDr. Fričová Dominika, PhD. |
| Duration: | 1.5.2023 – 30.4.2026 |
| Neu-Vasc – Neurovaskulárne poškodenie určuje patofyziológiu ochorenia u detských pacientov po traumatickom poškodení mozgu: zdroj nových biomarkerov | |
| Neurovascular damage determines disease pathophysiology in pediatric mild traumatic brain injury: source of new biomarkers | |
| Program: | ERANET |
| Project leader: | doc. RNDr. Filipčík Peter, CSc. |
| Duration: | 1.1.2020 – 31.12.2025 |
| premodiALS – Rukopis pre-motorického štádia amytrofnej laterálnej sklerózy | |
| A premotor disease signature for ALS | |
| Program: | Horizon 2020 |
| Project leader: | doc. MVDr. Žilka Norbert, DrSc. |
| Duration: | 1.9.2022 – 31.8.2025 |
| INTERTAU – Integrative structural biology of pathological tau protein, an appealing therapeutic target for Alzheimer´s disease modifying drugs | |
| Integrative structural biology of pathological tau protein, an appealing therapeutic target for Alzheimer´s disease modifying drugs | |
| Program: | Horizon 2020 |
| Project leader: | RNDr. Škrabana Rostislav, PhD. |
| Duration: | 1.6.2022 – 30.6.2025 |
| Antineuropatho – Vývoj nových nanoliečiv proti bakteriálnym infekciám v centrálnom nervovom systéme | |
| Developing novel nanopharmaceutics against bacterial infections at center nervous system | |
| Program: | ERANET |
| Project leader: | prof. MVDr. Bhide Mangesh Ramesh, PhD. |
| Duration: | 1.1.2022 – 31.12.2024 |
| ADDITION – Sledovanie dôležitých individuálnych výstupov pacientov s Alzheimerovou chorobou | |
| Alzheimer’s disease data-driven insights on individual outcomes of importance | |
| Program: | Horizon 2020 |
| Project leader: | Dr. h. c. prof. MVDr. Novák Michal, DrSc. |
| Duration: | 1.5.2019 – 30.9.2023 |
| Bridging the gap between science, education and enterprise in regenerative medicine | |
| Bridging the gap between science, education and enterprise in regenerative medicine | |
| Program: | Multilateral – other |
| Project leader: | prof. MVDr. Čížková Daša, DrSc. |
| Duration: | 1.10.2020 – 20.3.2022 |
| Nanosystémy konjugované s fragmentami protilátok na liečbu infekcií mozgu | |
| Nanosystems conjugated with antibody fragments for treating brain infections | |
| Program: | ERANET |
| Project leader: | prof. MVDr. Bhide Mangesh Ramesh, PhD. |
| Duration: | 1.1.2019 – 31.12.2021 |
| Tryptofán kynurenínová signálna dráha v tauopátiách a jej neuroprotektívna úloha s využitím v terapii | |
| The tryptophan kynurenine pathway – therapeutic strategy for neuroprotection in tauopathies | |
| Program: | ICGEB |
| Project leader: | PharmDr. Kováč Andrej, PhD. |
| Duration: | 1.1.2019 – 31.12.2021 |
| JPsustaiND – Coordination Action in support of the sustainability and globalisation of the Joint Programming Initiative on Neurodegenerative Diseases | |
| Coordination Action in support of the sustainability and globalisation of the Joint Programming Initiative on Neurodegenerative Diseases | |
| Program: | Horizon 2020 |
| Project leader: | Dr. h. c. prof. MVDr. Novák Michal, DrSc. |
| Duration: | 1.11.2015 – 30.4.2021 |
| AxonRepair – Obnova miechy: regenerácia axónov uvoľnením vnútro–neurónového prenosu | |
| Spinal cord repair: releasing the neuron-intrinsic brake on axon regeneration | |
| Program: | ERANET |
| Project leader: | prof. MVDr. Čížková Daša, DrSc. |
| Duration: | 1.1.2017 – 31.12.2019 |
| Repetitive Subconcussive Head Impacts -Brain Alterations and Clinical Consequences | |
| Repetitive Subconcussive Head Impacts -Brain Alterations and Clinical Consequences | |
| Program: | ERANET |
| Project leader: | doc. RNDr. Filipčík Peter, CSc. |
| Duration: | 1.1.2017 – 31.12.2019 |
| REfrAME – Mechanizmy patologickej transformácie proteínov pri neurodegeneračných ochoreniach: nové prístupy vyhodnotenia rizík a vývoj modelov | |
| Pathway complexities of protein misfolding in neurodegenerative diseases: a novel approach to risks evaluation and model development | |
| Program: | Horizon 2020 |
| Project leader: | Dr. h. c. prof. MVDr. Novák Michal, DrSc. |
| Duration: | 1.5.2016 – 30.4.2019 |
| NGP-NET – Ne-globulárne bielkoviny, ich sekvencia, štruktúra, funkcia a zapojenie v molekulárnej normálnej a patologickej fyziológii | |
| Non-globular proteins – from sequence to structure, function and application in molecular physiopathology (NGP-NET) | |
| Program: | COST |
| Project leader: | RNDr. Škrabana Rostislav, PhD. |
| Annotation: | Non-globular proteins (NGPs) encompass different molecular phenomena that defy the traditional sequence-structure-function paradigm. NGPs include intrinsically disordered regions, tandem repeats, aggregating domains, low-complexity sequences and transmembrane domains. Although growing evidence suggests that NGPs are central to many human diseases, functional annotation is very limited. It was recently estimated that close to 40 of all residues in the human proteome lack functional annotation and many of these are NGPs. While a better understanding of NGPs is crucial to fully comprehend human molecular physiopathology, progress has been hampered so far by the lack of a systematic approach to their study.This Action Proposal aims to create a pan-European scientific network of groups that work on NGPs to strengthen, focus and coordinate research in this field. It proposes to develop a novel classification of NGPs by consensus among interested experts that will be showcased on a newly developed web site, along with meetings, training schools and scientific missions on NGP-related topics. |
| Duration: | 31.5.2015 – 25.3.2019 |
| BIOMARKAPD – Biomarkery pre Alzheimerovu a Parkinsonovu chorobu | |
| Biomarkers for Alzheimer’s disease and Parkinson’s disease | |
| Program: | Multilateral – other |
| Project leader: | doc. MVDr. Žilka Norbert, DrSc. |
| Annotation: | Neurodegenerative disorders, represented mostly by Alzheimer’s disease (AD) and Parkinson’sdisease (PD), are characterised by progressive neuronal impairment and death. In spite of the brain’sknown capacity for regeneration, lost neurons generally cannot be replaced. Therefore, drugs aimedat inhibiting neurodegenerative processes are likely to be most effective if the treatment is initiated asearly as possible in the disease process. However, clinical manifestations in early disease stages areoften difficult to diagnose. This is where biomarkers, specifically reflecting the onset of pathology mayhave a profound impact on diagnosis and detection of treatment effects in the near future. A triplet ofcerebrospinal fluid (CSF) biomarkers for AD, total and hyperphosphorylated tau that reflect AD-typeaxonal degeneration, and the 42 amino acid isoform of amyloid beta that reflects senile plaque pathology, has already been established for early detection of AD before the onset of dementia. With regards to PD, the most promising biomarker is CSF alpha-synuclein. However, large variations in all biomarker measurements have been reported between studies, both between and within centres andlaboratories. Such variations may be caused by pre-analytical, analytical, or assay-related factors andseriously jeopardize the introduction of biomarkers in clinical routine and trials around the world. |
| Duration: | 1.6.2012 – 1.6.2015 |
| NANONET – Nanomechanika sietí intermediálnych filamentov | |
| NANOMECHANICS OF INTERMEDIATE FILAMENT NETWORKS – NANONET | |
| Program: | COST |
| Project leader: | doc. MVDr. Žilka Norbert, DrSc. |
| Duration: | 25.5.2010 – 24.5.2014 |
| Patologické štiepenie tau: samoobnovujúci sa propagátor neurofibrilárnej degenerácie v Alzheimerovej chorobe | |
| Tau truncation: the self-renewing propagator of neurofibrillary degeneration in Alzheimer’s disease | |
| Program: | UNIDO |
| Project leader: | Mgr. Kováčech Branislav, PhD. |
| Duration: | 1.1.2011 – 31.12.2013 |
| JUMPAHEAD – Koordinačná aktivita na podporu implementácia inociatívy Spoločné programovanie v boji proti neurodegenračným ochoreniam, zvlášť Alzheimerovej chorobe. | |
| COORDINATION ACTION IN SUPPORT OF THE IMPLEMENTATION OF A JOINT PROGRAMMING INITIATIVE FOR COMBATING NEURODEGENERATIVE DISEASES, IN PARTICULAR ALZHEIMER‘S DISEASE | |
| Program: | FP7 |
| Project leader: | Dr. h. c. prof. MVDr. Novák Michal, DrSc. |
| Duration: | 1.9.2010 – 31.8.2013 |
| ALCOVE – Spoločná európska evaluácia problematiky Alzheimerovej choroby | |
| ALzheimer COoperative Valuation in Europe | |
| Program: | Multilateral – other |
| Project leader: | Dr. h. c. prof. MVDr. Novák Michal, DrSc. |
| Duration: | 1.4.2011 – 31.3.2013 |
| Fosforylovaný tau proteínu ako biomarker porúch chovania v priebehu neurodegenerácie | |
| The role of phosphorylated tau protein in behavioral decline during neurodegeneration | |
| Program: | Bilateral – other |
| Project leader: | Dr. h. c. prof. MVDr. Novák Michal, DrSc. |
| Duration: | 1.1.2010 – 31.12.2011 |
| Nesprávne zvinutý tau proteín a antioxidačné obranné systémy v tauopátiách | |
| Misfolded tau protein and oxidative defense system in tauopathies | |
| Program: | UNIDO |
| Project leader: | doc. RNDr. Filipčík Peter, CSc. |
| Duration: | 1.1.2009 – 31.12.2011 |
National
| Analýza psychoneuroimunologických parametrov zdravia vo vybraných skupinách slovenskej populácie | |
| Analysis of Psychoneuroimmunological Parameters of Health in Specific Population Groups in Slovakia | |
| Program: | SRDA |
| Project leader: | prof. RNDr. Kontseková Eva, DrSc. |
| Duration: | 1.7.2023 – 30.6.2027 |
| Identifikácia nových biomarkerov a signálnych dráh po traumatickom poranení mozgu | |
| Identification of novel biomarkers and signaling pathways after traumatic brain injury | |
| Program: | VEGA |
| Project leader: | RNDr. Čente Martin, PhD. |
| Duration: | 1.1.2023 – 31.12.2026 |
| K agregácii náchylná konformácia proteínu tau rozpoznateľná špecifickými protilátkami | |
| Aggregation prone conformation of protein tau targetable by specific antibodies | |
| Program: | VEGA |
| Project leader: | Ing. Cehlár Ondrej, PhD. |
| Duration: | 1.1.2023 – 31.12.2026 |
| Vplyv celkovej anestézie na dynamiku zmien markerov mozgového poškodenia pri operáciách kraniosynostóz v dojčenskom veku | |
| – | |
| Program: | VEGA |
| Project leader: | MUDr. Parrák Vojtech |
| Duration: | 1.1.2023 – 31.12.2026 |
| Vplyv špecifickej štruktúry filamentov tau proteínu na indukciu periférnych biomarkerov pre diagnostiku chronickej traumatickej encefalopátie a ďalších tauopátií | |
| Specific structure of tau protein filaments as triggers of diagnostic peripheral biomarkers for diagnostic of chronic traumatic encephalopathy and other tauopathies | |
| Program: | VEGA |
| Project leader: | RNDr. Škrabana Rostislav, PhD. |
| Duration: | 1.1.2023 – 31.12.2026 |
| Celospoločenský dopad úrazov mozgu v Slovenskej Republike | |
| Whole-of-societal Impact of Traumatic Brain Injuries in Slovakia | |
| Program: | SRDA |
| Project leader: | RNDr. Čente Martin, PhD. |
| Duration: | 1.7.2023 – 30.6.2026 |
| Manažment rizík poranenia mozgu u hráčov kontaktných športov – diagnostika a prevencia neurodegenerácie | |
| Management of Brain Injury Risks in Contact Sport Players – Diagnosis and Prevention of Neurodegeneration | |
| Program: | SRDA |
| Project leader: | doc. RNDr. Filipčík Peter, CSc. |
| Duration: | 1.7.2023 – 30.6.2026 |
| Nový pohľad na mechanizmus tauopatií: lipidy ako nástroj na kontrolu procesu neurodegenerácie a neurozápalu | |
| Novel insights into Tauopathy mechanism: lipids as a tool to control neurodegeneration and neuroinflammation | |
| Program: | SRDA |
| Project leader: | Mgr. Majerová Petra, PhD. |
| Duration: | 1.7.2023 – 30.6.2026 |
| Štipendiá pre excelentných výskumníkov ohrozených vojnovým konfliktom na Ukrajine | |
| – | |
| Program: | Other projects |
| Project leader: | doc. Hryntsová Natalia Borisovna, PhD. |
| Duration: | 15.3.2023 – 14.3.2026 |
| Štipendiá pre excelentných výskumníkov ohrozených vojnovým konfliktom na Ukrajine | |
| – | |
| Program: | Other projects |
| Project leader: | Lykhota Olena Borysivna, PhD. |
| Duration: | 15.10.2022 – 14.10.2025 |
| Dvojsečný meč plazminogénového systému: Od udržiavania homeostázy po COVID-19 | |
| The double-edged sword of the plasminogen system: From homeostasis maintenance to COVID-19 | |
| Program: | SRDA |
| Project leader: | RNDr. Škrabana Rostislav, PhD. |
| Duration: | 1.8.2021 – 30.6.2025 |
| Longitudinálne monitorovanie adaptívnej imunity po infekcii SARS-CoV-2 a očkovaní: markery imunity | |
| Longitudinal monitoring of adaptive immunity after SARS-CoV -2 infection and vaccination: markers of imunity | |
| Program: | SRDA |
| Project leader: | prof. RNDr. Kontseková Eva, DrSc. |
| Duration: | 1.7.2022 – 30.6.2025 |
| Malé štruktúrované motívy ako regulátory patofyziológie prirodzene neusporiadaného tau proteínu | |
| Small ordered motifs in regulation of pathophysiology of disordered protein tau | |
| Program: | SRDA |
| Project leader: | RNDr. Škrabana Rostislav, PhD. |
| Duration: | 1.7.2022 – 30.6.2025 |
| Neuro-gliový multi-bunkový model pre šírenie tau patológie | |
| Neuro-glia cell-based model for inter-neuronal spread of tau pathology | |
| Program: | SRDA |
| Project leader: | RNDr. Žilková Monika, PhD. |
| Duration: | 1.7.2021 – 30.6.2025 |
| Nový receptorom sprostredkovaný systém pre transport liečiv do mozgu | |
| Novel receptor-mediated delivery system for brain therapeutics | |
| Program: | SRDA |
| Project leader: | Ing. Hanes Jozef, DrSc. |
| Duration: | 1.7.2022 – 30.6.2025 |
| Štúdium mechanizmu pohybu tau proteínu v CNS | |
| Mechanism of tau protein movement through and out of the brain | |
| Program: | SRDA |
| Project leader: | PharmDr. Kováč Andrej, PhD. |
| Duration: | 1.7.2022 – 30.6.2025 |
| Určenie úlohy dopamínu a neurogenézy v dospelosti pre naučené správanie spevavcov pomocou optogenetickej manipulácie | |
| Examining the role of dopamine and adult neurogenesis in learned behavior of songbirds using optogenetic manipulation | |
| Program: | SRDA |
| Project leader: | MUDr. Mgr. Hromádka Tomáš, PhD. |
| Duration: | 1.7.2021 – 30.6.2025 |
| Interakcia mozgu a čreva v podmienkach neurodegenerácie Alzeheimerovho typu | |
| Interaction of the brain and intestine in conditions of Alzeheimer\’s type neurodegeneration | |
| Program: | VEGA |
| Project leader: | MVDr. Mgr. Smolek Tomáš, PhD. |
| Duration: | 1.1.2022 – 31.12.2024 |
| Laktoferín a laktofericín ako prirodzené inhibítory plazmínu: Od určenia štruktúry po terapeutické aplikácie | |
| – | |
| Program: | VEGA |
| Project leader: | RNDr. Škrabana Rostislav, PhD. |
| Duration: | 1.1.2021 – 31.12.2024 |
| Navrhovanie nanoterapeutík proti Západonílskemu vírusu – Ako model v boji proti neuroinfekciám | |
| Engineering the nano-therapeutics against West Nile virus- A model to contend neuroinfections | |
| Program: | VEGA |
| Project leader: | Kulkarni Amod, M.Sc., PhD. |
| Duration: | 1.1.2021 – 31.12.2024 |
| Nové terapeutické ciele pre liečbu traumatického poškodenia mozgu a ich validácia v animálnom modeli chronickej neurodegenerácie | |
| New therapeutic targets for treatment of traumatic brain injury and their validation in animal model of chronic neurodegeneration | |
| Program: | VEGA |
| Project leader: | doc. RNDr. Filipčík Peter, CSc. |
| Duration: | 1.1.2022 – 31.12.2024 |
| Receptorom sprostredkovaný transport liečiv cez hematoencefalickú bariéru do mozgu | |
| Novel receptor-mediated delivery system for brain therapeutics | |
| Program: | VEGA |
| Project leader: | PharmDr. Kováč Andrej, PhD. |
| Duration: | 1.1.2022 – 31.12.2024 |
| Vplyv gliových buniek na šírenie tau patológie v neuro-gliovom bunkovom modeli pre Alzheimerovu chorobu | |
| The effect of glial cells on tau spreading in neuro-glia cell-based model for Alzheimer’s disease | |
| Program: | VEGA |
| Project leader: | RNDr. Žilková Monika, PhD. |
| Duration: | 1.1.2022 – 31.12.2024 |
| Úloha senescencie v neuurodegenerácii: od molekulárnych mechanizmov po inovatívne stratégie v liečbe | |
| The role of senescence in neurodegeneration: from the molecular connection to the application and novel treatment strategies | |
| Program: | SASPRO |
| Project leader: | MUDr. RNDr. Fričová Dominika, PhD. |
| Duration: | 1.10.2021 – 30.9.2024 |
| Longitudinálne pozorovanie neurodegenerácie a korelátov relevantných ukazovateľov v Ach | |
| Longitudinal Assessment of Neurodegeneration and the Correlates of Relevant Endpoints in AD | |
| Program: | SRDA |
| Project leader: | MUDr. Novák Petr, PhD. |
| Duration: | 1.7.2021 – 30.6.2024 |
| Molekulové dráhy indukované traumatickým poškodením mozgu: identifikácia nových biomarkerov a potenciálnych terapeutických cieľov pre neurodegeneráciu | |
| Molecular pathways induced by traumatic brain injury: novel biomarkers and prediction of new therapeutic targets for neurodegeneration | |
| Program: | SRDA |
| Project leader: | doc. RNDr. Filipčík Peter, CSc. |
| Duration: | 1.7.2021 – 30.6.2024 |
| Šírenie patológie asociovanej s alfa-Synukleínom naprieč orgánmi gastrointestinálneho traktu v myšom modeli a pacientov s Parkinsonovou chorobou | |
| Spread of alpha-Synuclein-associated pathology across gastrointestinal organs in a mouse model and patients with Parkinson\’s disease | |
| Program: | SRDA |
| Project leader: | MUDr. RNDr. Fričová Dominika, PhD. |
| Duration: | 1.7.2021 – 30.6.2024 |
| Biomarkery neurozápalu u pacientov s Alzheimerovou chorobou | |
| – | |
| Program: | VEGA |
| Project leader: | MUDr. Mgr. Hromádka Tomáš, PhD. |
| Duration: | 1.1.2020 – 31.12.2023 |
| Identifikácia a validácia nových cieľových molekúl za účelom vývoja nových liečiv na Alzheimerovu chorobu | |
| Identification and validation of novel targets for Alzheimer’s diseases | |
| Program: | VEGA |
| Project leader: | Ing. Hanes Jozef, DrSc. |
| Duration: | 1.1.2021 – 31.12.2023 |
| Štúdium mechanizmu transportu tau proteínu cez hematolikvorovú bariéru v neurodegeneratívnych ochoreniach | |
| Study of tau transport across blood-cerebrospinal fluid barrier in neurodegenerative disorders | |
| Program: | VEGA |
| Project leader: | Mgr. Majerová Petra, PhD. |
| Duration: | 1.1.2021 – 31.12.2023 |
| Úloha senescencie v neurodegenerácii | |
| The role of senescence in neurodegeneration | |
| Program: | VEGA |
| Project leader: | MUDr. RNDr. Fričová Dominika, PhD. |
| Duration: | 1.1.2021 – 31.12.2023 |
| Inhibičné kortikálne obvody kognitívnej dysfunkcie pri Alzheimerovej Chorobe | |
| Inhibitory cortical circuits mediating cognitive dysfunction in Alzheimer’s disease | |
| Program: | SRDA |
| Project leader: | MUDr. Mgr. Hromádka Tomáš, PhD. |
| Duration: | 1.7.2020 – 30.6.2023 |
| Kognitívne dopady športových úrazov mozgu u adolescentov v Slovenskej republike | |
| Cognitive consequences of sport-related traumatic brain injuries in adolescents in the Slovak Republic | |
| Program: | SRDA |
| Project leader: | doc. RNDr. Filipčík Peter, CSc. |
| Duration: | 1.7.2020 – 30.6.2023 |
| Dlhé nekódujúce RNA ako biomarkery Alzheimerovej choroby | |
| Long non-coding RNAs as biomarkers of Alzheimer\’s disease | |
| Program: | VEGA |
| Project leader: | RNDr. Čente Martin, PhD. |
| Duration: | 1.1.2019 – 31.12.2022 |
| Konformačné vlastnosti prirodzene neusporiadaného proteínu tau so zameraním na C-koniec jeho molekuly | |
| Conformational properties of intrinsically disordered protein tau with the emphasis on the C-terminus of its molecule | |
| Program: | VEGA |
| Project leader: | Ing. Cehlár Ondrej, PhD. |
| Duration: | 1.1.2019 – 31.12.2022 |
| Mechanizmus alostérickej regulácie neusporiadaných proteínov: štruktúra a interakčný potenciál projekčnej domény tau proteínu u rôznych izoforiem | |
| Intriguing allostery of a disordered protein: cooperation between tau protein projection domain and microtubule-binding repeats | |
| Program: | VEGA |
| Project leader: | RNDr. Škrabana Rostislav, PhD. |
| Duration: | 1.1.2019 – 31.12.2022 |
| Vplyv neurofibrilárnej patológie na meningy u transgénneho modelu tauopátie | |
| – | |
| Program: | VEGA |
| Project leader: | Jadhav Santosh, M.Sc., PhD. |
| Duration: | 1.1.2020 – 31.12.2022 |
| Molekulové biomarkery ochorení mozgu u psov – Monitorovanie regenerácie mozgového tkaniva a účinnosti terapie | |
| Molecular biomarkers for canine brain disorders – Monitoring of the brain regeneration and efficacy of treatment | |
| Program: | SRDA |
| Project leader: | doc. MVDr. Žilka Norbert, DrSc. |
| Duration: | 1.7.2019 – 30.6.2022 |
| Vývoj nových prístupov na terapiu tauopatií využívajúcich transportné peptidy pre liečivá a protilátky do mozgu | |
| The development of novel approaches for therapy of tauopathies using transport peptides for drugs and antibodies into the brain | |
| Program: | SRDA |
| Project leader: | PharmDr. Kováč Andrej, PhD. |
| Duration: | 1.7.2019 – 30.6.2022 |
| Cerebrovaskulárne a zápalové zmeny hematoencefalickej bariéry v ľudských tauopatiách | |
| Neuroinflammatory changes of the blood-brain barrier in AD, CBD and PSP | |
| Program: | VEGA |
| Project leader: | Mgr. Brezováková Veronika |
| Duration: | 1.1.2019 – 31.12.2021 |
| Charakterizácia vzťahu medzi neurofibrilárnou patológiou a diabetom | |
| An investigation into the link between neurofibrillary degeneration and diabetes | |
| Program: | VEGA |
| Project leader: | PharmDr. Kováč Andrej, PhD. |
| Duration: | 1.1.2019 – 31.12.2021 |
| Liečba poranenia miechy implantáciou decelularizovanej matrix ľudského pupočníkového tkaniva | |
| Treatment of spinal cord injury using implantation of umbilical cord decellularized matrix | |
| Program: | VEGA |
| Project leader: | prof. MUDr. Syková Eva, DrSc. |
| Duration: | 1.1.2019 – 31.12.2021 |
| Podprahové otrasy mozgu ako rizikový faktor chronickej traumatickej encefalopatie | |
| Sub-concussive head trauma as risk factor for chronic traumatic encephalopathy | |
| Program: | VEGA |
| Project leader: | doc. RNDr. Filipčík Peter, CSc. |
| Duration: | 1.1.2019 – 31.12.2021 |
| Vývoj terapeutických biomolekúl blokujúcich SARS-CoV-2 infekciu | |
| Development of therapeutic biomolecules blocking SARS-COV-2 infection | |
| Program: | SRDA |
| Project leader: | prof. RNDr. Kontseková Eva, DrSc. |
| Duration: | 16.9.2020 – 31.12.2021 |
| ASTRO-AD – 3D in vitro model Alzheimerovej choroby s využitím astrocytov derivovaných z ľudských indukovaných pluripotentných kmeňových buniek | |
| 3D In vitro Modelling of Alzheimer’s Disease using Astrocytes derived from Induced Pluripotent Stem Cells | |
| Program: | SRDA |
| Project leader: | prof. MUDr. Syková Eva, DrSc. |
| Duration: | 1.8.2018 – 30.6.2021 |
| TraumiRNA – Identifikácia molekulových mechanizmov indukovaných traumatickým poškodením mozgu u hráčov ľadového hokeja | |
| Identification of molecular mechanisms induced by traumatic brain injury in ice hockey players | |
| Program: | SRDA |
| Project leader: | doc. RNDr. Filipčík Peter, CSc. |
| Duration: | 1.8.2018 – 30.6.2021 |
| Neuronálne koreláty kognitívnej dysfunkcie Alzheimerovej choroby | |
| Neuronal correlates of cognitive dysfunction in Alzheimer`s disease | |
| Program: | VEGA |
| Project leader: | MVDr. Maté Veronika, PhD. |
| Duration: | 1.1.2018 – 31.12.2020 |
| Tryptofán kynurenínová signálna dráha v tauopátiách a jej neuroprotektívna úloha s využitím v terapii | |
| The tryptophan kynurenine pathway- therapeutic strategy for neuroprotection in tauopathies | |
| Program: | VEGA |
| Project leader: | Mgr. Majerová Petra, PhD. |
| Duration: | 1.1.2018 – 31.12.2020 |
| Vplyv patologického Tau proteínu na neuronálnu diferenciáciu a mitochondriálny metabolizmus | |
| Effect of pathological Tau protein on neuronal differentiation and mitochondrial metabolism | |
| Program: | VEGA |
| Project leader: | MVDr. Fialová Ľubica, PhD. |
| Duration: | 1.1.2018 – 31.12.2020 |
| Využitie zvieracích modelov pre tauopátie na identifikáciu molekulárnych dráh podieľajúcich sa na etiológii neurofibrilárnej degenerácie | |
| Use of animal models for tauopathies for identification of molecular pathways involved in the etiology of neurofibrillary degeneration | |
| Program: | VEGA |
| Project leader: | Ing. Hanes Jozef, DrSc. |
| Duration: | 1.1.2018 – 31.12.2020 |
| TAUPET – Vývoj nových neurozobrazovacích prístupov na predklinickú diagnostiku tauopatií využívajúcich transportné peptidy pre tau-špecifické nanoprotilátky | |
| Development of new neuro-imaging approaches for preclinical diagnosis of tauopathies using transport peptides for tau specific nanobodies | |
| Program: | Other projects |
| Project leader: | PharmDr. Kováč Andrej, PhD. |
| Duration: | 1.12.2018 – 31.12.2020 |
| Zmeny v hladine cirkulujúcich miRNA u hráčov ľadového hokeja po úrazoch hlavy: potenciálny marker poškodenia mozgu | |
| Changes in plasmatic miRNA level in ice-hockey players after the head injury: potential marker of traumatic brain injury | |
| Program: | VEGA |
| Project leader: | prof. RNDr. Kontseková Eva, DrSc. |
| Duration: | 1.1.2018 – 31.12.2020 |
| Štúdium funkčných bio-implantátov a bunkovej terapia pre regeneráciu CNS | |
| Study of functional bio-implants and cell therapy for the CNS regeneration | |
| Program: | SRDA |
| Project leader: | prof. MVDr. Čížková Daša, DrSc. |
| Duration: | 1.7.2016 – 30.6.2020 |
| Využitie animálnych modelov pre tauopátie na identifikáciu molekulárnych dráh podieľajúcich sa na etiológii neurofibrilárnej degenerácie | |
| Use of animal models for tauopathies for identification of molecular pathways involved in the etiology of neurofibrillary degeneration | |
| Program: | SRDA |
| Project leader: | Mgr. Kováčech Branislav, PhD. |
| Duration: | 1.7.2017 – 30.6.2020 |
| Imunogenetické markery u slovenských pacientov s Alzheimerovou chorobou | |
| Immunogenetic markers in Slovak patients with Alzheimer´s disease | |
| Program: | VEGA |
| Project leader: | MUDr. Mgr. Hromádka Tomáš, PhD. |
| Duration: | 1.1.2016 – 31.12.2019 |
| Modelovanie interakčných mechanizmov medzi neurónmi a gliovými bunkami v Alzheimerovej chorobe | |
| Modeling of interactions between neurons and glial cells in Alzheimer\’s disease | |
| Program: | VEGA |
| Project leader: | RNDr. Žilková Monika, PhD. |
| Duration: | 1.1.2017 – 31.12.2019 |
| Vplyv stravy bohatej na tuky na fyziólogiu neurónov CNS, funkciu synapsií a pathologické procesy v neurodegenerácii | |
| The effect of high-fat diet on the physiology of CNS neurons, their synapses and pathological processes in neurodegeneration | |
| Program: | VEGA |
| Project leader: | Jadhav Santosh, M.Sc., PhD. |
| Duration: | 1.1.2017 – 31.12.2019 |
| MEITEC_PRE_CNS – Vývoj MEtódy na stratifikáciu pacientov po traumatickom poškodení mozgu a Identifikáciu nových TErapeutických Cieľov PRE personalizovanú liečbu a prevenciu neurodegenerácie | |
| – | |
| Program: | Other projects |
| Project leader: | doc. RNDr. Filipčík Peter, CSc. |
| Duration: | 1.12.2018 – 31.12.2019 |
| Dokáže aktívna stimulácia mozgu zastaviť šírenie neurofibrilárnej degenerácie? | |
| Is it possible to stop the spreading of neurofibrillary degeneration by active stimulation of the brain? | |
| Program: | VEGA |
| Project leader: | doc. MVDr. Žilka Norbert, DrSc. |
| Duration: | 1.1.2016 – 31.12.2018 |
| Inhibícia expresie prirodzene nezvinutých proteínov a jej dôsledky pre progresiu neurodegeneratívnych zmien | |
| Inhibtion of expression of natively unfolded proteins and its consequence for progression of neurodegeneration | |
| Program: | VEGA |
| Project leader: | doc. RNDr. Filipčík Peter, CSc. |
| Duration: | 1.1.2016 – 31.12.2018 |
| MOLEKULÁRNY PROFIL MIRNA A ZMENY GÉNOVEJ EXPRESIE V MODELI ĽUDSKÝCH TAUOPATIÍ | |
| Molecular profiling of miRNA and gene expression changes in a model of human tauopathy | |
| Program: | VEGA |
| Project leader: | RNDr. Čente Martin, PhD. |
| Duration: | 1.1.2015 – 31.12.2018 |
| Starnutie imunitného systému a biologické markery imunosenescencie | |
| The aging of the immune system and biomarkers of human immunosenescence | |
| Program: | VEGA |
| Project leader: | RNDr. Prčina Michal, PhD. |
| Duration: | 1.1.2016 – 31.12.2018 |
| ŠTRUKTÚRA SEKVENČNE HOMOLÓGNYCH EPITOPOV VIACNÁSOBNE PRÍTOMNÝCH NA MOLEKULE PRIRODZENE NEUSPORIADANÉHO PROTEÍNU TAU | |
| Structural study of multiple homologous epitopes present on the molecule of intrinsically disordered protein tau | |
| Program: | VEGA |
| Project leader: | Ing. Cehlár Ondrej, PhD. |
| Duration: | 1.1.2015 – 31.12.2018 |
| Zmeny funkcie kôrových neurónov pri Alzheimerovej chorobe | |
| Functional impact of Alzheimer\’s disease on cortical neurons | |
| Program: | VEGA |
| Project leader: | MUDr. Mgr. Hromádka Tomáš, PhD. |
| Duration: | 1.1.2016 – 31.12.2018 |
| MODEL BUNKOVEJ KOMUNIKÁCIE MEDZI NERVOVÝM A IMUNITNÝM SYSTÉMOM V ALZHEIMEROVEJ CHOROBE | |
| The model of the neuroimmune crosstalk in Alzheimer´s disease | |
| Program: | SRDA |
| Project leader: | doc. MVDr. Žilka Norbert, DrSc. |
| Duration: | 1.7.2015 – 30.6.2018 |
| VÝVOJ NOVÉHO PEPTIDOVÉHO SYSTÉMU PRE TRANSPORT LIEČIV DO MOZGU | |
| Development of novel peptide based system for delivery of therapeutics into the brain | |
| Program: | SRDA |
| Project leader: | PharmDr. Kováč Andrej, PhD. |
| Duration: | 1.7.2015 – 30.6.2018 |
| Nová kombinovaná terapia na báze alginátových biomateriálov a trofických faktorov pre obnovu poranenej miechy | |
| A novel combined therapy based on alginate biomaterials and trophic factors for spinal cord injury repair | |
| Program: | SRDA |
| Project leader: | prof. MVDr. Čížková Daša, DrSc. |
| Duration: | 1.1.2016 – 31.12.2017 |
| POŠKODENIE MOZGOVO-CIEVNEJ BARIÉRY V PROSTREDÍ NEURODEGENERÁCIE U TRANSGÉNNYCH POTKANÍCH MODELOV PRE TAUOPÁTIE | |
| Damage of the blood-brain barrier of transgenic rat models for tauopathies | |
| Program: | VEGA |
| Project leader: | PharmDr. Kováč Andrej, PhD. |
| Duration: | 1.1.2015 – 31.12.2017 |
| BIOFYZIKÁLNA ANALÝZA N-KONCOVEJ DOMÉNY PROTEÍNU TAU MODEL PRE PRIRODZENE NEUSPORIADANÝ POLYPEPTID: DÔSLEDKY PRE NEURODEGENERAČNÉ TAUOPÁTIE | |
| Biophysics and structure of intrinsically disordered polypeptides studied on the N-terminal tail of tau protein: implications for neurodegenerative tauopathies | |
| Program: | VEGA |
| Project leader: | RNDr. Škrabana Rostislav, PhD. |
| Duration: | 1.1.2013 – 31.12.2016 |
| KONVERZIA NEURONÁLNÉHO PROTEÍNU TAU NA PATOLOGICKÉ FORMY VO ZVIERACOM MODELI NEUROFIBRILÁRNEJ DEGENERÁCIE | |
| Conversion of the neuronal protein tau into pathological forms in the animal model of neurofibrillary degeneration | |
| Program: | VEGA |
| Project leader: | Mgr. Kováčech Branislav, PhD. |
| Duration: | 1.1.2013 – 31.12.2016 |
| MOLEKULÁRNE MECHANIZMY DYSREGULÁCIE PROTEOSTÁZY V NEURODEGENERATÍVNYCH PROTEINOPÁTIÁCH | |
| Identification of molecular mechanisms underlying dysregulated proteostasis in neurodegenerative proteinopathy | |
| Program: | VEGA |
| Project leader: | RNDr. Žilková Monika, PhD. |
| Duration: | 1.1.2014 – 31.12.2016 |
| ETIOPATOGENÉZA NEURODEGENERATÍVNYCH OCHORENÍ: VÝZNAM POSTTRANSKRIPČNEJ ÚPRAVY RNA PRE VZNIK A PROGRESIE SPORADICKÝCH TAUOPÁTIÍ A ALZHEIMEROVEJ CHOROBY | |
| Etiopathogenesis of neurodegenerative diseases: focus on RNA processing regulation in development and progression of sporadic tauopathies and Alzheimer´s disease | |
| Program: | SRDA |
| Project leader: | doc. RNDr. Filipčík Peter, CSc. |
| Duration: | 1.10.2013 – 30.9.2016 |
| ŠTÚDIUM FUNKCIE TAU PROTEÍNU V JADRÁCH NEURÓNOV | |
| Studies of tau protein functions in nuclei of neurons | |
| Program: | VEGA |
| Project leader: | Mgr. Baráth Peter, PhD. |
| Annotation: | Neurofibrillary tangles, one of the hallmarks of Alzheimer\’s disease (AD),are composed of missfolded tau protein that belongs to the family of microtubule-associated proteins. The transition between normal and pathological tau proteins is driven by post-translational modifications and partial proteolytic cleavage. It is generally assumed that the main function of tau involves regulation of the dynamics of neuronal microtubules. Recently, this typical cytosolic protein has been shown to translocate to the nucleus where it might participate in DNA protection upon stress. Within the project, we will study nuclear tau shuttling mechanism using cellular models expressing truncated forms, some of which cause development of AD-like symptoms in transgenic rat. We will also explore the mechanism of DNA protection that includes description of nuclear tau interactome and FISH analysis of chromosomal regions recognized by tau. The study will provide new perspective on physiological and pathological roles of tau protein. |
| Duration: | 1.1.2012 – 31.12.2015 |
| UBIQUITÍN- PROTEAZÓMOVÝ SYSTÉM A JEHO AKTIVITA V BUNKOVOM MODELY NEURODEGRADÁCIE: IMPLIKÁCIE PRE ETIOPATOGENÉZU DEGENERATÍVNYCH OCHORENÍ MOZGU | |
| Ubiquitin proteasomal system and it’s activity in cellular model of neurodegeneration: implications for etiopathogenesis of degenerative diseases of brain | |
| Program: | VEGA |
| Project leader: | doc. RNDr. Filipčík Peter, CSc. |
| Duration: | 1.1.2013 – 31.12.2015 |
| Brain centrum – CENTRUM EXCELENTNOSTI PRE VÝSKUM MOZGU SAV | |
| – | |
| Program: | Centrá excelentnosti SAV |
| Project leader: | doc. MVDr. Žilka Norbert, DrSc. |
| Duration: | 4.8.2011 – 3.8.2015 |
| MECHANIZMUS INTERAKCIE IMUNITNÉHO A NERVOVÉHO SYSTÉMU V PROCESE NEURODEGENERÁCIE MOZGU | |
| Mechnism of immune and neuronal system interaction in the brain during neurodegeneration | |
| Program: | SRDA |
| Project leader: | RNDr. Žilková Monika, PhD. |
| Duration: | 1.7.2012 – 30.6.2015 |
| RIZIKOVÉ FAKTORY A PROTEOMICKÝ RUKOPIS KOGNITÍVNYCH DYSFUNKCIÍ ANIMÁLNYCH MODELOV PRE ĽUDSKÉ DEMENCIE | |
| Risk factors and proteomic signature of cognitive dysfunctions in animal models for human dementias | |
| Program: | SRDA |
| Project leader: | doc. MVDr. Žilka Norbert, DrSc. |
| Duration: | 1.7.2012 – 30.6.2015 |
| ANALÝZY INERAKČNÝCH PARTNEROV PRIÓNOVÉHO PROTEÍNU A ICH FUNKČNÝ VÝZNAM | |
| Analysis of prion protein interaction partners and their functional significance | |
| Program: | VEGA |
| Project leader: | prof. RNDr. Kontseková Eva, DrSc. |
| Duration: | 1.1.2012 – 31.12.2014 |
| VPLYV RNA SEKUNDÁRNEJ ŠTRUKTÚRY NA EFEKTIVITU ZOSTRIHU PREKURZOROVEJ MRNA. IMPLIKÁCIA PRE REGULÁCIU SYNTÉZY TAU EXÓN 10 +/- IZOFORIEM | |
| Effect RNA secondary structure on RNA splicing effciency. Implication for regulation sythesis of tau exon10 +/- | |
| Program: | VEGA |
| Project leader: | Mgr. Královičová Jana, PhD |
| Duration: | 1.1.2012 – 31.12.2014 |
| JE STRES JEDNÝM Z PODSTATNÝCH FAKTOROV NEURODEGENERAČNÉHO PROCESU PRI ALZHEIMEROVEJ CHOROBE? | |
| Is stress a crucial factor in the process of neurodegeneration accompanying Alzheimer´s disease? | |
| Program: | SRDA |
| Project leader: | doc. RNDr. Filipčík Peter, CSc. |
| Duration: | 1.5.2011 – 31.10.2014 |
| TauDecode – IDENTIFIKÁCIA POST-TRANSLAČNÝCH MODIFIKÁCIÍ NEURONÁLNEHO PROTEÍNU TAU ZODPOVEDNÝCH ZA NEUROFIBRILÁRNU DEGENERÁCIU V TAUOPÁTIÁCH. | |
| Identification of the posttranslational modifications of the neuronal protein tau leading to neurofibrillary degeneration in tauopathies | |
| Program: | SRDA |
| Project leader: | Mgr. Kováčech Branislav, PhD. |
| Annotation: | Neurofibrillary degeneration consisting of misfolded neuronal protein tau is the key pathological feature of tauopathies, affecting about 13% of people over the age of 65 and half of those over 85 in the developed countries. The extent of the tau pathology directly correlates with the clinical progression of the disease. It is assumed that halting the tau misfolding process in neurofibrillary pathology would lead to successful therapies preventing the cognitive decline. Hyperphosphorylation and truncation of tau are thought to play the principal role in the induction of its pathology. However, the identity and temporal order of the individual phosphorylation events (there are 45 confirmed phospho-sites on tau) that are required for its misfolding have not been revealed, yet. Furthermore, the temporal relationship of truncation and phosphorylation events on tau is also unknown. In this project we will address the question of the identity and temporal order of the individual phosphorylation patterns and truncation events in the misfolding process of normal tau protein into insoluble aggregates. We will use a unique rat model faithfully reproducing all aspects of the complete cascade of human neurofibrillary degeneration. The results will thus provide a clue for the understanding the paradox how can a highly soluble structureless flexible protein turn insoluble and highly structured in the disease. |
| Duration: | 1.5.2011 – 30.4.2014 |
| ANALÝZA BIOMARKEROV V CEREBROSPINÁLNEJ TEKUTINE TRANSGÉNNYCH ANIMÁLNYCH MODELOV PRE ĽUDSKÉ TAUOPATIE. | |
| Analysis of biomarkers in cerebrospinal fluid in transgenic animal models for human tauopathies. | |
| Program: | VEGA |
| Project leader: | MUDr. Kosoň Peter, PhD. |
| Duration: | 1.1.2011 – 31.12.2013 |
| METABOLOMICKÁ ANALÝZA POTKANIEHO MODELU PRE TAUOPÁTIE. | |
| Metabolomic analysis of rat model of tauopathy. | |
| Program: | VEGA |
| Project leader: | Dr. h. c. prof. MVDr. Novák Michal, DrSc. |
| Duration: | 1.1.2011 – 31.12.2013 |
| MITOCHONDRIÁLNE OXIDAČNO-REDUKČNÉ SIGNÁLNE DRÁHY V PATOGENÉZE DEGENERÁCIE CENTRÁLNEHO NERVOVÉHO SYSTÉMU. | |
| Mitochondrial redox signaling pathways in the pathogenesis of degeneration of central nervous system. | |
| Program: | VEGA |
| Project leader: | RNDr. Čente Martin, PhD. |
| Duration: | 1.1.2011 – 31.12.2013 |
| MOLEKULOVÝ MECHANIZMUS BUNKOVEJ SMRTI PRI ALZHEIMEROVEJ CHOROBE. | |
| Molecular mechanism of cell death in Alzheimer’s disease. | |
| Program: | VEGA |
| Project leader: | RNDr. Žilková Monika, PhD. |
| Duration: | 1.1.2011 – 31.12.2013 |
| PROTEOMICKÁ ANALÝZA ZDRAVÉHO A CHORÉHO TAU PROTEÍNU U ALZHEIMEROVEJ CHOROBY. | |
| Proteomic analysis of physiological and pathological tau protein by Alzheimer´s disease. | |
| Program: | VEGA |
| Project leader: | MUDr. Novák Petr, PhD. |
| Duration: | 1.1.2011 – 31.12.2013 |
| ŠTÚDIUM RÔZNYCH ÚNIKOVÝCH STRATÉGIÍ NEUROINVAZÍVNYCH KMEŇOV FRANCISELLA A BORRELIA PRED KOMPLEMENTOVÝM SYSTÉMOM. | |
| Study of multiple complement evasion strategies used by neuroinvasive Francisella and Borrelia. | |
| Program: | VEGA |
| Project leader: | Prof. MVDr. Mikula Ivan, DrSc. |
| Duration: | 1.1.2011 – 31.12.2013 |
| ZÁPALOVÉ DRÁHY OVPLYVNENÉ GENETICKÝM POZADÍM V TAUOPATII. | |
| Inflammatory pathways influenced by the gentic background in tauopathy. | |
| Program: | VEGA |
| Project leader: | doc. MVDr. Žilka Norbert, DrSc. |
| Duration: | 1.1.2011 – 31.12.2013 |
| KOMPLEXNÝ VÝSKUM ŠTRUKTÚRY PRIRODZENE NEUSPORIADANÉHO PROTEÍNU TAU VYSTUPUJÚCEHO V NEURODEGENERAČNÝCH OCHORENIACH. | |
| Complex approach to structural study of intrinsically disordered protein tau associated with neurodegenerations. | |
| Program: | SRDA |
| Project leader: | RNDr. Škrabana Rostislav, PhD. |
| Duration: | 1.9.2009 – 31.8.2013 |
| SKRÍNINGOVÝ SYSTÉM PRE IDENTIFIKÁCIU POTENCIÁLNYCH BIOLOGICKÝCH MARKEROV PRE SKORÚ DIAGNOSTIKU PARKINSONOVEJ CHOROBY | |
| – | |
| Program: | EU Structural Funds Research & Development |
| Project leader: | doc. RNDr. Filipčík Peter, CSc. |
| Duration: | 1.11.2010 – 30.4.2013 |
| MOLEKULOVÉ MECHANIZMY NEUROTOXICITY INDUKOVANÉ EXPRESIOU PRIRODZENE NEZVINUTÝCH PROTEÍNOV. | |
| Molecular mechanisms of neurotoxicity induced by expression of naturaly unfolded proteins | |
| Program: | VEGA |
| Project leader: | doc. RNDr. Filipčík Peter, CSc. |
| Duration: | 1.1.2010 – 31.12.2012 |
| MONOKLONOVÉ PROTILÁTKY AKO NÁSTROJ NA ANALÝZU KONFORMAČNÝCH ZMIEN TAU PROTEÍNU PRI ALZHEIMEROVEJ CHOROBE | |
| Monoclonal antibodies as a tool for study of conformational changes of tau protein in Alzheimer´s disease | |
| Program: | VEGA |
| Project leader: | RNDr. Paulenka-Ivanovová Natália, PhD. |
| Duration: | 1.1.2010 – 31.12.2012 |
| PRIRODZENE NEZVINUTÝ PROTEÍN TAU A JEHO ŠTRUKTURÁLNE ZMENY ANALYZOVANÉ POMOCOU IMUNOLOGICKÉHO IMPRINTU – KONFORMAČNE-ZÁVISLEJ MONOKLONOVEJ PROTILÁTKY | |
| Intrinsically disordered protein tau and its structural changes analyzed by its immunological imprint – conformation-specific monoclonal antibody | |
| Program: | VEGA |
| Project leader: | Mgr. Kováčech Branislav, PhD. |
| Duration: | 1.1.2010 – 31.12.2012 |
| ŠTÚDIUM ŠTVRTEJ MIKROTUBULY-VIAŽÚCEJ OBLASTI NEUSPORIADANÉHO PROTEÍNU TAU KOMPLEMENTÁRNYMI METÓDAMI ŠTRUKTÚRNEJ BIOLÓGIE VO VZŤAHU K FYZIOLÓGII A PATOLÓGII TAU | |
| Fourth microtubule-binding region of disordered tau protein studied by complementary methods of structural biology: insight into its role in physiology and pathology | |
| Program: | VEGA |
| Project leader: | RNDr. Škrabana Rostislav, PhD. |
| Duration: | 1.1.2010 – 31.12.2012 |
| VPLYV PATOLOGICKÝCH FORIEM TAU PROTEÍNU NA ŠTRUKTURÁLNE ZMENY NEUROVASKULÁRNEJ JEDNOTKY U POTKANIEHO MODELU PRE ALZHEIMEROVU CHOROBU | |
| Impact of pathological forms of tau protein on structural changes of neurovascular unit in the rat model of Alzheimer’s disease | |
| Program: | VEGA |
| Project leader: | Ing. Bugoš Ondrej, PhD |
| Duration: | 1.1.2010 – 31.12.2012 |
| TRANSKRIPČNÁ A PROTEOMICKÁ ANALÝZA OXIDAČNO-REDUKČNÉHO SYSTÉMU V NEURÓNOCH EXPRIMUJÚCICH PATOLOGICKÉ FORMY PROTEÍNU TAU | |
| Transcriptional and proteomic analysis of redox system in neurons expressing pathological tau protein isoforms | |
| Program: | SRDA |
| Project leader: | doc. RNDr. Filipčík Peter, CSc. |
| Duration: | 1.9.2009 – 31.8.2012 |
| PRIONÓZY PRENOSNÉ NA ČLOVEKA: VÝSKUM A VÝVOJ BUNKOVÉHO MODELU S POTENCIÁLNYM VYUŽITÍM V APLIKAČNEJ SFÉRE. | |
| – | |
| Program: | EU Structural Funds Research & Development |
| Project leader: | prof. RNDr. Kontseková Eva, DrSc. |
| Duration: | 1.10.2009 – 30.11.2011 |
| IMUNITA V TAUOPATIÁCH – DOPAD AKTIVÁCIE A SUPRESIE IMUNITNÉHO SYSTÉMU NA NEURODEGENERÁCIU V TRANSGÉNNOM MODELI POTKANA EXPRIMUJÚCOM SKRÁTENÚ FORMU TAU PROTEÍNU | |
| – | |
| Program: | SRDA |
| Project leader: | Ing. Hanes Jozef, DrSc. |
| Duration: | 1.9.2009 – 31.8.2011 |
| potkan ako model – Molekulová analýza postranslačných modifikácii tau proteínu v priebehu ontogenézy potkana a ich význam pre modelovanie tau kaskády pri tauopatiách. | |
| Molecular analysis of postranslational modifications of tau protein during ontogenesis of rat and their implication for modelling of tau cascade in tauopathies. | |
| Program: | SRDA |
| Project leader: | prof. RNDr. Kontseková Eva, DrSc. |
| Duration: | 1.6.2008 – 31.12.2010 |
| Nesprávne zvinutý tau proteín a antioxidačné obranné systémy v tauopátiách | |
| Misfolded tau protein and oxidative defense system in tauopathies | |
| Program: | Podpora MVTS z prostriedkov SAV |
| Project leader: | doc. RNDr. Filipčík Peter, CSc. |
| Duration: | 1.1.2010 – 31.12.2010 |
| Rekonštrukcia neurofibrilárnej degenerácie Alzheimerovho typu v jednej bunke. | |
| In vitro reconstruction of Alzheimer’s disease type neurofibrillary degeneration | |
| Program: | VEGA |
| Project leader: | RNDr. Čente Martin, PhD. |
| Duration: | 1.1.2008 – 31.12.2010 |
| Tvorba, akumulácia a degradácia aberantných proteínov v patogenéze chronických neurodegeneračných ochorení centrálneho nervového systému | |
| Generation, accumulation and degradation of aberrant proteins in the pathogenesis of chronic neurodegenerative diseases of central nervous system | |
| Program: | SRDA |
| Project leader: | doc. RNDr. Filipčík Peter, CSc. |
| Duration: | 1.6.2008 – 31.12.2010 |
| Využitie kmeňových buniek pre imunomodulačnú a regeneračnú liečbu neurodegeneračných a zápalových procesov spojených s Alzheimerovou chorobou | |
| Regenerative and immunomodulatory cell therapy of Alzheimer’s disease neurodegeneration using bone marrow stem cell clones | |
| Program: | SRDA |
| Project leader: | doc. MVDr. Žilka Norbert, DrSc. |
| Duration: | 1.6.2008 – 31.12.2010 |
| Tauopátie: Molekulová analýza hyperfosforylovaných foriem tau proteínu a ich vplyv na poškodenie kognitívnych a senzorimotorickych funkcií transgénnych potkanov | |
| Tauopathies: Molecular analysis of the hyperphosphorylated forms of the tau protein and their impact on the deterioration of the cognitive and sensorimotor functions of the transgenic rats. | |
| Program: | VEGA |
| Project leader: | RNDr. Stožická Zuzana, PhD. |
| Duration: | 1.1.2008 – 1.1.2010 |
| DNA analýza familiárnych foriem tauopátií na Slovensku | |
| DNA analysis of familial forms of tauopathies in Slovakia | |
| Program: | SRDA |
| Project leader: | Dr. h. c. prof. MVDr. Novák Michal, DrSc. |
| Duration: | 1.2.2007 – 31.12.2009 |
| Fyziologické štr – Štruktúra fyziologických konformácií prirodzene neusporiadaneho proteínu tau: dôsledky pre neurodegeneráciu Alzheimerovho typu | |
| Structure of physiological conformations of intrinsically disordered tau protein: implications for Alzheimer\’s type of neurodegeneration | |
| Program: | SRDA |
| Project leader: | RNDr. Škrabana Rostislav, PhD. |
| Duration: | 1.2.2007 – 31.12.2009 |
| Biochemické aspekty konverzie priónového proteínu PrP c na patologickú formu PrP Sc | |
| Biochemical aspects of normal form prion protein PrP c conversion into the pathological PrP Sc | |
| Program: | VEGA |
| Project leader: | RNDr. Imrichová Denisa, PhD |
| Duration: | 1.1.2007 – 1.12.2009 |
| Inhibítory tau fosforylácie ako modulátory patogenézy pri Alzheimerovej chorobe | |
| Inhibitors of tau phosphorylation as modulators of Alzheimer s disease pathogenesis | |
| Program: | VEGA |
| Project leader: | Ing. Hanes Jozef, DrSc. |
| Duration: | 1.1.2007 – 1.12.2009 |
| Nitrácia tau proteínov ako potenciálne významný rizikový faktor v patogenéze Alzheimerovej choroby | |
| Nitration of tau proteins as potentially important risk factor in the pathogenesis of Alzheimer s disease | |
| Program: | VEGA |
| Project leader: | doc. RNDr. Filipčík Peter, CSc. |
| Duration: | 1.1.2007 – 1.12.2009 |