View projects over the past five years.
International
| Sledovanie dôležitých individuálnych výstupov pacientov s Alzheimerovou chorobou | |
| Alzheimer’s disease data-driven insights on individual outcomes of importance | |
| Program: | Horizon 2020 |
| Project leader: | Dr. h. c. prof. MVDr. Novák Michal, DrSc. |
| Duration: | 1.5.2019 – 30.4.2022 |
| Bridging the gap between science, education and enterprise in regenerative medicine | |
| Bridging the gap between science, education and enterprise in regenerative medicine | |
| Program: | Multilateral – other |
| Project leader: | prof. MVDr. Čížková Daša, DrSc. |
| Duration: | 1.10.2020 – 20.3.2022 |
| Nanosystémy konjugované s fragmentami protilátok na liečbu infekcií mozgu | |
| Nanosystems conjugated with antibody fragments for treating brain infections | |
| Program: | ERANET |
| Project leader: | doc. MVDr. Bhide Mangesh Ramesh, PhD. |
| Duration: | 1.1.2019 – 31.12.2021 |
| Tryptofán kynurenínová signálna dráha v tauopátiách a jej neuroprotektívna úloha s využitím v terapii | |
| The tryptophan kynurenine pathway – therapeutic strategy for neuroprotection in tauopathies | |
| Program: | ICGEB |
| Project leader: | PharmDr. Kováč Andrej, PhD. |
| Duration: | 1.1.2019 – 31.12.2021 |
| JPsustaiND – Coordination Action in support of the sustainability and globalisation of the Joint Programming Initiative on Neurodegenerative Diseases | |
| Coordination Action in support of the sustainability and globalisation of the Joint Programming Initiative on Neurodegenerative Diseases | |
| Program: | Horizon 2020 |
| Project leader: | Dr. h. c. prof. MVDr. Novák Michal, DrSc. |
| Duration: | 1.11.2015 – 30.4.2021 |
| AxonRepair – Obnova miechy: regenerácia axónov uvoľnením vnútro–neurónového prenosu | |
| Spinal cord repair: releasing the neuron-intrinsic brake on axon regeneration | |
| Program: | ERANET |
| Project leader: | prof. MVDr. Čížková Daša, DrSc. |
| Duration: | 1.1.2017 – 31.12.2019 |
| Repetitive Subconcussive Head Impacts -Brain Alterations and Clinical Consequences | |
| Repetitive Subconcussive Head Impacts -Brain Alterations and Clinical Consequences | |
| Program: | ERANET |
| Project leader: | doc. RNDr. Filipčík Peter, CSc. |
| Duration: | 1.1.2017 – 31.12.2019 |
| REfrAME – Mechanizmy patologickej transformácie proteínov pri neurodegeneračných ochoreniach: nové prístupy vyhodnotenia rizík a vývoj modelov | |
| Pathway complexities of protein misfolding in neurodegenerative diseases: a novel approach to risks evaluation and model development | |
| Program: | Horizon 2020 |
| Project leader: | Dr. h. c. prof. MVDr. Novák Michal, DrSc. |
| Duration: | 1.5.2016 – 30.4.2019 |
| NGP-NET – Ne-globulárne bielkoviny, ich sekvencia, štruktúra, funkcia a zapojenie v molekulárnej normálnej a patologickej fyziológii | |
| Non-globular proteins – from sequence to structure, function and application in molecular physiopathology (NGP-NET) | |
| Program: | COST |
| Project leader: | RNDr. Škrabana Rostislav, PhD. |
| Annotation: | Non-globular proteins (NGPs) encompass different molecular phenomena that defy the traditional sequence-structure-function paradigm. NGPs include intrinsically disordered regions, tandem repeats, aggregating domains, low-complexity sequences and transmembrane domains. Although growing evidence suggests that NGPs are central to many human diseases, functional annotation is very limited. It was recently estimated that close to 40 of all residues in the human proteome lack functional annotation and many of these are NGPs. While a better understanding of NGPs is crucial to fully comprehend human molecular physiopathology, progress has been hampered so far by the lack of a systematic approach to their study.This Action Proposal aims to create a pan-European scientific network of groups that work on NGPs to strengthen, focus and coordinate research in this field. It proposes to develop a novel classification of NGPs by consensus among interested experts that will be showcased on a newly developed web site, along with meetings, training schools and scientific missions on NGP-related topics. |
| Duration: | 31.5.2015 – 25.3.2019 |
National
| Molekulové biomarkery ochorení mozgu u psov – Monitorovanie regenerácie mozgového tkaniva a účinnosti terapie | |
| Molecular biomarkers for canine brain disorders – Monitoring of the brain regeneration and efficacy of treatment | |
| Program: | SRDA |
| Project leader: | doc. MVDr. Žilka Norbert, DrSc. |
| Duration: | 1.7.2019 – 30.6.2022 |
| Vývoj nových prístupov na terapiu tauopatií využívajúcich transportné peptidy pre liečivá a protilátky do mozgu | |
| The development of novel approaches for therapy of tauopathies using transport peptides for drugs and antibodies into the brain | |
| Program: | SRDA |
| Project leader: | PharmDr. Kováč Andrej, PhD. |
| Duration: | 1.7.2019 – 30.6.2022 |
| Cerebrovaskulárne a zápalové zmeny hematoencefalickej bariéry v ľudských tauopatiách | |
| Neuroinflammatory changes of the blood-brain barrier in AD, CBD and PSP | |
| Program: | VEGA |
| Project leader: | Mgr. Brezováková Veronika |
| Duration: | 1.1.2019 – 31.12.2021 |
| Charakterizácia vzťahu medzi neurofibrilárnou patológiou a diabetom | |
| An investigation into the link between neurofibrillary degeneration and diabetes | |
| Program: | VEGA |
| Project leader: | PharmDr. Kováč Andrej, PhD. |
| Duration: | 1.1.2019 – 31.12.2021 |
| Liečba poranenia miechy implantáciou decelularizovanej matrix ľudského pupočníkového tkaniva | |
| Treatment of spinal cord injury using implantation of umbilical cord decellularized matrix | |
| Program: | VEGA |
| Project leader: | prof. MUDr. Syková Eva, DrSc. |
| Duration: | 1.1.2019 – 31.12.2021 |
| Podprahové otrasy mozgu ako rizikový faktor chronickej traumatickej encefalopatie | |
| Sub-concussive head trauma as risk factor for chronic traumatic encephalopathy | |
| Program: | VEGA |
| Project leader: | doc. RNDr. Filipčík Peter, CSc. |
| Duration: | 1.1.2019 – 31.12.2021 |
| Vývoj terapeutických biomolekúl blokujúcich SARS-CoV-2 infekciu | |
| Development of therapeutic biomolecules blocking SARS-COV-2 infection | |
| Program: | SRDA |
| Project leader: | prof. RNDr. Kontseková Eva, DrSc. |
| Duration: | 16.9.2020 – 31.12.2021 |
| ASTRO-AD – 3D in vitro model Alzheimerovej choroby s využitím astrocytov derivovaných z ľudských indukovaných pluripotentných kmeňových buniek | |
| 3D In vitro Modelling of Alzheimer’s Disease using Astrocytes derived from Induced Pluripotent Stem Cells | |
| Program: | SRDA |
| Project leader: | prof. MUDr. Syková Eva, DrSc. |
| Duration: | 1.8.2018 – 30.6.2021 |
| TraumiRNA – Identifikácia molekulových mechanizmov indukovaných traumatickým poškodením mozgu u hráčov ľadového hokeja | |
| Identification of molecular mechanisms induced by traumatic brain injury in ice hockey players | |
| Program: | SRDA |
| Project leader: | doc. RNDr. Filipčík Peter, CSc. |
| Duration: | 1.8.2018 – 30.6.2021 |
| Neuronálne koreláty kognitívnej dysfunkcie Alzheimerovej choroby | |
| Neuronal correlates of cognitive dysfunction in Alzheimer`s disease | |
| Program: | VEGA |
| Project leader: | MVDr. Maté Veronika, PhD. |
| Duration: | 1.1.2018 – 31.12.2020 |
| Tryptofán kynurenínová signálna dráha v tauopátiách a jej neuroprotektívna úloha s využitím v terapii | |
| The tryptophan kynurenine pathway- therapeutic strategy for neuroprotection in tauopathies | |
| Program: | VEGA |
| Project leader: | Mgr. Majerová Petra, PhD. |
| Duration: | 1.1.2018 – 31.12.2020 |
| Vplyv patologického Tau proteínu na neuronálnu diferenciáciu a mitochondriálny metabolizmus | |
| Effect of pathological Tau protein on neuronal differentiation and mitochondrial metabolism | |
| Program: | VEGA |
| Project leader: | MVDr. Fialová Ľubica, PhD. |
| Duration: | 1.1.2018 – 31.12.2020 |
| Využitie zvieracích modelov pre tauopátie na identifikáciu molekulárnych dráh podieľajúcich sa na etiológii neurofibrilárnej degenerácie | |
| Use of animal models for tauopathies for identification of molecular pathways involved in the etiology of neurofibrillary degeneration | |
| Program: | VEGA |
| Project leader: | Ing. Hanes Jozef, DrSc. |
| Duration: | 1.1.2018 – 31.12.2020 |
| TAUPET – Vývoj nových neurozobrazovacích prístupov na predklinickú diagnostiku tauopatií využívajúcich transportné peptidy pre tau-špecifické nanoprotilátky | |
| Development of new neuro-imaging approaches for preclinical diagnosis of tauopathies using transport peptides for tau specific nanobodies | |
| Program: | Other projects |
| Project leader: | PharmDr. Kováč Andrej, PhD. |
| Duration: | 1.12.2018 – 31.12.2020 |
| Zmeny v hladine cirkulujúcich miRNA u hráčov ľadového hokeja po úrazoch hlavy: potenciálny marker poškodenia mozgu | |
| Changes in plasmatic miRNA level in ice-hockey players after the head injury: potential marker of traumatic brain injury | |
| Program: | VEGA |
| Project leader: | prof. RNDr. Kontseková Eva, DrSc. |
| Duration: | 1.1.2018 – 31.12.2020 |
| Štúdium funkčných bio-implantátov a bunkovej terapia pre regeneráciu CNS | |
| Study of functional bio-implants and cell therapy for the CNS regeneration | |
| Program: | SRDA |
| Project leader: | prof. MVDr. Čížková Daša, DrSc. |
| Duration: | 1.7.2016 – 30.6.2020 |
| Využitie animálnych modelov pre tauopátie na identifikáciu molekulárnych dráh podieľajúcich sa na etiológii neurofibrilárnej degenerácie | |
| Use of animal models for tauopathies for identification of molecular pathways involved in the etiology of neurofibrillary degeneration | |
| Program: | SRDA |
| Project leader: | Mgr. Kováčech Branislav, PhD. |
| Duration: | 1.7.2017 – 30.6.2020 |
| Imunogenetické markery u slovenských pacientov s Alzheimerovou chorobou | |
| Immunogenetic markers in Slovak patients with Alzheimer´s disease | |
| Program: | VEGA |
| Project leader: | MUDr. Mgr. Hromádka Tomáš, PhD. |
| Duration: | 1.1.2016 – 31.12.2019 |
| Modelovanie interakčných mechanizmov medzi neurónmi a gliovými bunkami v Alzheimerovej chorobe | |
| Modeling of interactions between neurons and glial cells in Alzheimer\’s disease | |
| Program: | VEGA |
| Project leader: | RNDr. Žilková Monika, PhD. |
| Duration: | 1.1.2017 – 31.12.2019 |
| Vplyv stravy bohatej na tuky na fyziólogiu neurónov CNS, funkciu synapsií a pathologické procesy v neurodegenerácii | |
| The effect of high-fat diet on the physiology of CNS neurons, their synapses and pathological processes in neurodegeneration | |
| Program: | VEGA |
| Project leader: | Jadhav Santosh, M.Sc., PhD. |
| Duration: | 1.1.2017 – 31.12.2019 |
| MEITEC_PRE_CNS – Vývoj MEtódy na stratifikáciu pacientov po traumatickom poškodení mozgu a Identifikáciu nových TErapeutických Cieľov PRE personalizovanú liečbu a prevenciu neurodegenerácie | |
| – | |
| Program: | Other projects |
| Project leader: | doc. RNDr. Filipčík Peter, CSc. |
| Duration: | 1.12.2018 – 31.12.2019 |
| Dokáže aktívna stimulácia mozgu zastaviť šírenie neurofibrilárnej degenerácie? | |
| Is it possible to stop the spreading of neurofibrillary degeneration by active stimulation of the brain? | |
| Program: | VEGA |
| Project leader: | doc. MVDr. Žilka Norbert, DrSc. |
| Duration: | 1.1.2016 – 31.12.2018 |
| Inhibícia expresie prirodzene nezvinutých proteínov a jej dôsledky pre progresiu neurodegeneratívnych zmien | |
| Inhibtion of expression of natively unfolded proteins and its consequence for progression of neurodegeneration | |
| Program: | VEGA |
| Project leader: | doc. RNDr. Filipčík Peter, CSc. |
| Duration: | 1.1.2016 – 31.12.2018 |
| MOLEKULÁRNY PROFIL MIRNA A ZMENY GÉNOVEJ EXPRESIE V MODELI ĽUDSKÝCH TAUOPATIÍ | |
| Molecular profiling of miRNA and gene expression changes in a model of human tauopathy | |
| Program: | VEGA |
| Project leader: | RNDr. Čente Martin, PhD. |
| Duration: | 1.1.2015 – 31.12.2018 |
| Starnutie imunitného systému a biologické markery imunosenescencie | |
| The aging of the immune system and biomarkers of human immunosenescence | |
| Program: | VEGA |
| Project leader: | RNDr. Prčina Michal, PhD. |
| Duration: | 1.1.2016 – 31.12.2018 |
| ŠTRUKTÚRA SEKVENČNE HOMOLÓGNYCH EPITOPOV VIACNÁSOBNE PRÍTOMNÝCH NA MOLEKULE PRIRODZENE NEUSPORIADANÉHO PROTEÍNU TAU | |
| Structural study of multiple homologous epitopes present on the molecule of intrinsically disordered protein tau | |
| Program: | VEGA |
| Project leader: | Ing. Cehlár Ondrej, PhD. |
| Duration: | 1.1.2015 – 31.12.2018 |
| Zmeny funkcie kôrových neurónov pri Alzheimerovej chorobe | |
| Functional impact of Alzheimer\’s disease on cortical neurons | |
| Program: | VEGA |
| Project leader: | MUDr. Mgr. Hromádka Tomáš, PhD. |
| Duration: | 1.1.2016 – 31.12.2018 |
| MODEL BUNKOVEJ KOMUNIKÁCIE MEDZI NERVOVÝM A IMUNITNÝM SYSTÉMOM V ALZHEIMEROVEJ CHOROBE | |
| The model of the neuroimmune crosstalk in Alzheimer´s disease | |
| Program: | SRDA |
| Project leader: | doc. MVDr. Žilka Norbert, DrSc. |
| Duration: | 1.7.2015 – 30.6.2018 |
| VÝVOJ NOVÉHO PEPTIDOVÉHO SYSTÉMU PRE TRANSPORT LIEČIV DO MOZGU | |
| Development of novel peptide based system for delivery of therapeutics into the brain | |
| Program: | SRDA |
| Project leader: | PharmDr. Kováč Andrej, PhD. |
| Duration: | 1.7.2015 – 30.6.2018 |
| Nová kombinovaná terapia na báze alginátových biomateriálov a trofických faktorov pre obnovu poranenej miechy | |
| A novel combined therapy based on alginate biomaterials and trophic factors for spinal cord injury repair | |
| Program: | SRDA |
| Project leader: | prof. MVDr. Čížková Daša, DrSc. |
| Duration: | 1.1.2016 – 31.12.2017 |
| POŠKODENIE MOZGOVO-CIEVNEJ BARIÉRY V PROSTREDÍ NEURODEGENERÁCIE U TRANSGÉNNYCH POTKANÍCH MODELOV PRE TAUOPÁTIE | |
| Damage of the blood-brain barrier of transgenic rat models for tauopathies | |
| Program: | VEGA |
| Project leader: | PharmDr. Kováč Andrej, PhD. |
| Duration: | 1.1.2015 – 31.12.2017 |