View projects over the past five years.
International
| INTERTAU – Integrative structural biology of pathological tau protein, an appealing therapeutic target for Alzheimer´s disease modifying drugs | |
| Integrative structural biology of pathological tau protein, an appealing therapeutic target for Alzheimer´s disease modifying drugs | |
| Program: | Horizon 2020 |
| Project leader: | RNDr. Škrabana Rostislav, PhD. |
| Duration: | 1.6.2022 – 30.6.2025 |
| ADDITION – Sledovanie dôležitých individuálnych výstupov pacientov s Alzheimerovou chorobou | |
| Alzheimer’s disease data-driven insights on individual outcomes of importance | |
| Program: | Horizon 2020 |
| Project leader: | Dr. h. c. prof. MVDr. Novák Michal, DrSc. |
| Duration: | 1.5.2019 – 30.9.2023 |
| Bridging the gap between science, education and enterprise in regenerative medicine | |
| Bridging the gap between science, education and enterprise in regenerative medicine | |
| Program: | Multilateral – other |
| Project leader: | prof. MVDr. Čížková Daša, DrSc. |
| Duration: | 1.10.2020 – 20.3.2022 |
| Nanosystémy konjugované s fragmentami protilátok na liečbu infekcií mozgu | |
| Nanosystems conjugated with antibody fragments for treating brain infections | |
| Program: | ERANET |
| Project leader: | prof. MVDr. Bhide Mangesh Ramesh, PhD. |
| Duration: | 1.1.2019 – 31.12.2021 |
| Tryptofán kynurenínová signálna dráha v tauopátiách a jej neuroprotektívna úloha s využitím v terapii | |
| The tryptophan kynurenine pathway – therapeutic strategy for neuroprotection in tauopathies | |
| Program: | ICGEB |
| Project leader: | PharmDr. Kováč Andrej, PhD. |
| Duration: | 1.1.2019 – 31.12.2021 |
| JPsustaiND – Coordination Action in support of the sustainability and globalisation of the Joint Programming Initiative on Neurodegenerative Diseases | |
| Coordination Action in support of the sustainability and globalisation of the Joint Programming Initiative on Neurodegenerative Diseases | |
| Program: | Horizon 2020 |
| Project leader: | Dr. h. c. prof. MVDr. Novák Michal, DrSc. |
| Duration: | 1.11.2015 – 30.4.2021 |
National
| Dvojsečný meč plazminogénového systému: Od udržiavania homeostázy po COVID-19 | |
| The double-edged sword of the plasminogen system: From homeostasis maintenance to COVID-19 | |
| Program: | SRDA |
| Project leader: | RNDr. Škrabana Rostislav, PhD. |
| Duration: | 1.8.2021 – 30.6.2025 |
| Longitudinálne monitorovanie adaptívnej imunity po infekcii SARS-CoV-2 a očkovaní: markery imunity | |
| Longitudinal monitoring of adaptive immunity after SARS-CoV -2 infection and vaccination: markers of imunity | |
| Program: | SRDA |
| Project leader: | prof. RNDr. Kontseková Eva, DrSc. |
| Duration: | 1.7.2022 – 30.6.2025 |
| Malé štruktúrované motívy ako regulátory patofyziológie prirodzene neusporiadaného tau proteínu | |
| Small ordered motifs in regulation of pathophysiology of disordered protein tau | |
| Program: | SRDA |
| Project leader: | RNDr. Škrabana Rostislav, PhD. |
| Duration: | 1.7.2022 – 30.6.2025 |
| Neuro-gliový multi-bunkový model pre šírenie tau patológie | |
| Neuro-glia cell-based model for inter-neuronal spread of tau pathology | |
| Program: | SRDA |
| Project leader: | RNDr. Žilková Monika, PhD. |
| Duration: | 1.7.2021 – 30.6.2025 |
| Nový receptorom sprostredkovaný systém pre transport liečiv do mozgu | |
| Novel receptor-mediated delivery system for brain therapeutics | |
| Program: | SRDA |
| Project leader: | Ing. Hanes Jozef, DrSc. |
| Duration: | 1.7.2022 – 30.6.2025 |
| Štúdium mechanizmu pohybu tau proteínu v CNS | |
| Mechanism of tau protein movement through and out of the brain | |
| Program: | SRDA |
| Project leader: | PharmDr. Kováč Andrej, PhD. |
| Duration: | 1.7.2022 – 30.6.2025 |
| Určenie úlohy dopamínu a neurogenézy v dospelosti pre naučené správanie spevavcov pomocou optogenetickej manipulácie | |
| Examining the role of dopamine and adult neurogenesis in learned behavior of songbirds using optogenetic manipulation | |
| Program: | SRDA |
| Project leader: | MUDr. Mgr. Hromádka Tomáš, PhD. |
| Duration: | 1.7.2021 – 30.6.2025 |
| Interakcia mozgu a čreva v podmienkach neurodegenerácie Alzeheimerovho typu | |
| Interaction of the brain and intestine in conditions of Alzeheimer\’s type neurodegeneration | |
| Program: | VEGA |
| Project leader: | MVDr. Mgr. Smolek Tomáš, PhD. |
| Duration: | 1.1.2022 – 31.12.2024 |
| Laktoferín a laktofericín ako prirodzené inhibítory plazmínu: Od určenia štruktúry po terapeutické aplikácie | |
| – | |
| Program: | VEGA |
| Project leader: | RNDr. Škrabana Rostislav, PhD. |
| Duration: | 1.1.2021 – 31.12.2024 |
| Navrhovanie nanoterapeutík proti Západonílskemu vírusu – Ako model v boji proti neuroinfekciám | |
| Engineering the nano-therapeutics against West Nile virus- A model to contend neuroinfections | |
| Program: | VEGA |
| Project leader: | Kulkarni Amod, M.Sc., PhD. |
| Duration: | 1.1.2021 – 31.12.2024 |
| Nové terapeutické ciele pre liečbu traumatického poškodenia mozgu a ich validácia v animálnom modeli chronickej neurodegenerácie | |
| New therapeutic targets for treatment of traumatic brain injury and their validation in animal model of chronic neurodegeneration | |
| Program: | VEGA |
| Project leader: | doc. RNDr. Filipčík Peter, CSc. |
| Duration: | 1.1.2022 – 31.12.2024 |
| Receptorom sprostredkovaný transport liečiv cez hematoencefalickú bariéru do mozgu | |
| Novel receptor-mediated delivery system for brain therapeutics | |
| Program: | VEGA |
| Project leader: | PharmDr. Kováč Andrej, PhD. |
| Duration: | 1.1.2022 – 31.12.2024 |
| Vplyv gliových buniek na šírenie tau patológie v neuro-gliovom bunkovom modeli pre Alzheimerovu chorobu | |
| The effect of glial cells on tau spreading in neuro-glia cell-based model for Alzheimer’s disease | |
| Program: | VEGA |
| Project leader: | RNDr. Žilková Monika, PhD. |
| Duration: | 1.1.2022 – 31.12.2024 |
| Longitudinálne pozorovanie neurodegenerácie a korelátov relevantných ukazovateľov v Ach | |
| Longitudinal Assessment of Neurodegeneration and the Correlates of Relevant Endpoints in AD | |
| Program: | SRDA |
| Project leader: | MUDr. Novák Petr, PhD. |
| Duration: | 1.7.2021 – 30.6.2024 |
| Molekulové dráhy indukované traumatickým poškodením mozgu: identifikácia nových biomarkerov a potenciálnych terapeutických cieľov pre neurodegeneráciu | |
| Molecular pathways induced by traumatic brain injury: novel biomarkers and prediction of new therapeutic targets for neurodegeneration | |
| Program: | SRDA |
| Project leader: | doc. RNDr. Filipčík Peter, CSc. |
| Duration: | 1.7.2021 – 30.6.2024 |
| Šírenie patológie asociovanej s alfa-Synukleínom naprieč orgánmi gastrointestinálneho traktu v myšom modeli a pacientov s Parkinsonovou chorobou | |
| Spread of alpha-Synuclein-associated pathology across gastrointestinal organs in a mouse model and patients with Parkinson\’s disease | |
| Program: | SRDA |
| Project leader: | MUDr. RNDr. Fričová Dominika, PhD. |
| Duration: | 1.7.2021 – 30.6.2024 |
| Štipendiá pre excelentných výskumníkov ohrozených vojnovým konfliktom na Ukrajine | |
| – | |
| Program: | Other projects |
| Project leader: | Lykhota Olena Borysivna, PhD. |
| Duration: | 15.10.2022 – 29.2.2024 |
| Biomarkery neurozápalu u pacientov s Alzheimerovou chorobou | |
| – | |
| Program: | VEGA |
| Project leader: | MUDr. Mgr. Hromádka Tomáš, PhD. |
| Duration: | 1.1.2020 – 31.12.2023 |
| Identifikácia a validácia nových cieľových molekúl za účelom vývoja nových liečiv na Alzheimerovu chorobu | |
| Identification and validation of novel targets for Alzheimer’s diseases | |
| Program: | VEGA |
| Project leader: | Ing. Hanes Jozef, DrSc. |
| Duration: | 1.1.2021 – 31.12.2023 |
| Štúdium mechanizmu transportu tau proteínu cez hematolikvorovú bariéru v neurodegeneratívnych ochoreniach | |
| Study of tau transport across blood-cerebrospinal fluid barrier in neurodegenerative disorders | |
| Program: | VEGA |
| Project leader: | Mgr. Majerová Petra, PhD. |
| Duration: | 1.1.2021 – 31.12.2023 |
| Úloha senescencie v neurodegenerácii | |
| The role of senescence in neurodegeneration | |
| Program: | VEGA |
| Project leader: | MUDr. RNDr. Fričová Dominika, PhD. |
| Duration: | 1.1.2021 – 31.12.2023 |
| Úloha senescencie v neuurodegenerácii: od molekulárnych mechanizmov po inovatívne stratégie v liečbe | |
| The role of senescence in neurodegeneration: from the molecular connection to the application and novel treatment strategies | |
| Program: | SASPRO |
| Project leader: | MUDr. RNDr. Fričová Dominika, PhD. |
| Duration: | 1.10.2021 – 31.12.2023 |
| Inhibičné kortikálne obvody kognitívnej dysfunkcie pri Alzheimerovej Chorobe | |
| Inhibitory cortical circuits mediating cognitive dysfunction in Alzheimer’s disease | |
| Program: | SRDA |
| Project leader: | MUDr. Mgr. Hromádka Tomáš, PhD. |
| Duration: | 1.7.2020 – 30.6.2023 |
| Kognitívne dopady športových úrazov mozgu u adolescentov v Slovenskej republike | |
| Cognitive consequences of sport-related traumatic brain injuries in adolescents in the Slovak Republic | |
| Program: | SRDA |
| Project leader: | doc. RNDr. Filipčík Peter, CSc. |
| Duration: | 1.7.2020 – 30.6.2023 |
| Dlhé nekódujúce RNA ako biomarkery Alzheimerovej choroby | |
| Long non-coding RNAs as biomarkers of Alzheimer\’s disease | |
| Program: | VEGA |
| Project leader: | RNDr. Čente Martin, PhD. |
| Duration: | 1.1.2019 – 31.12.2022 |
| Konformačné vlastnosti prirodzene neusporiadaného proteínu tau so zameraním na C-koniec jeho molekuly | |
| Conformational properties of intrinsically disordered protein tau with the emphasis on the C-terminus of its molecule | |
| Program: | VEGA |
| Project leader: | Ing. Cehlár Ondrej, PhD. |
| Duration: | 1.1.2019 – 31.12.2022 |
| Mechanizmus alostérickej regulácie neusporiadaných proteínov: štruktúra a interakčný potenciál projekčnej domény tau proteínu u rôznych izoforiem | |
| Intriguing allostery of a disordered protein: cooperation between tau protein projection domain and microtubule-binding repeats | |
| Program: | VEGA |
| Project leader: | RNDr. Škrabana Rostislav, PhD. |
| Duration: | 1.1.2019 – 31.12.2022 |
| Vplyv neurofibrilárnej patológie na meningy u transgénneho modelu tauopátie | |
| – | |
| Program: | VEGA |
| Project leader: | Jadhav Santosh, M.Sc., PhD. |
| Duration: | 1.1.2020 – 31.12.2022 |
| Molekulové biomarkery ochorení mozgu u psov – Monitorovanie regenerácie mozgového tkaniva a účinnosti terapie | |
| Molecular biomarkers for canine brain disorders – Monitoring of the brain regeneration and efficacy of treatment | |
| Program: | SRDA |
| Project leader: | doc. MVDr. Žilka Norbert, DrSc. |
| Duration: | 1.7.2019 – 30.6.2022 |
| Vývoj nových prístupov na terapiu tauopatií využívajúcich transportné peptidy pre liečivá a protilátky do mozgu | |
| The development of novel approaches for therapy of tauopathies using transport peptides for drugs and antibodies into the brain | |
| Program: | SRDA |
| Project leader: | PharmDr. Kováč Andrej, PhD. |
| Duration: | 1.7.2019 – 30.6.2022 |
| Cerebrovaskulárne a zápalové zmeny hematoencefalickej bariéry v ľudských tauopatiách | |
| Neuroinflammatory changes of the blood-brain barrier in AD, CBD and PSP | |
| Program: | VEGA |
| Project leader: | Mgr. Brezováková Veronika |
| Duration: | 1.1.2019 – 31.12.2021 |
| Charakterizácia vzťahu medzi neurofibrilárnou patológiou a diabetom | |
| An investigation into the link between neurofibrillary degeneration and diabetes | |
| Program: | VEGA |
| Project leader: | PharmDr. Kováč Andrej, PhD. |
| Duration: | 1.1.2019 – 31.12.2021 |
| Liečba poranenia miechy implantáciou decelularizovanej matrix ľudského pupočníkového tkaniva | |
| Treatment of spinal cord injury using implantation of umbilical cord decellularized matrix | |
| Program: | VEGA |
| Project leader: | prof. MUDr. Syková Eva, DrSc. |
| Duration: | 1.1.2019 – 31.12.2021 |
| Podprahové otrasy mozgu ako rizikový faktor chronickej traumatickej encefalopatie | |
| Sub-concussive head trauma as risk factor for chronic traumatic encephalopathy | |
| Program: | VEGA |
| Project leader: | doc. RNDr. Filipčík Peter, CSc. |
| Duration: | 1.1.2019 – 31.12.2021 |
| Vývoj terapeutických biomolekúl blokujúcich SARS-CoV-2 infekciu | |
| Development of therapeutic biomolecules blocking SARS-COV-2 infection | |
| Program: | SRDA |
| Project leader: | prof. RNDr. Kontseková Eva, DrSc. |
| Duration: | 16.9.2020 – 31.12.2021 |
| ASTRO-AD – 3D in vitro model Alzheimerovej choroby s využitím astrocytov derivovaných z ľudských indukovaných pluripotentných kmeňových buniek | |
| 3D In vitro Modelling of Alzheimer’s Disease using Astrocytes derived from Induced Pluripotent Stem Cells | |
| Program: | SRDA |
| Project leader: | prof. MUDr. Syková Eva, DrSc. |
| Duration: | 1.8.2018 – 30.6.2021 |
| TraumiRNA – Identifikácia molekulových mechanizmov indukovaných traumatickým poškodením mozgu u hráčov ľadového hokeja | |
| Identification of molecular mechanisms induced by traumatic brain injury in ice hockey players | |
| Program: | SRDA |
| Project leader: | doc. RNDr. Filipčík Peter, CSc. |
| Duration: | 1.8.2018 – 30.6.2021 |
| Neuronálne koreláty kognitívnej dysfunkcie Alzheimerovej choroby | |
| Neuronal correlates of cognitive dysfunction in Alzheimer`s disease | |
| Program: | VEGA |
| Project leader: | MVDr. Maté Veronika, PhD. |
| Duration: | 1.1.2018 – 31.12.2020 |
| Tryptofán kynurenínová signálna dráha v tauopátiách a jej neuroprotektívna úloha s využitím v terapii | |
| The tryptophan kynurenine pathway- therapeutic strategy for neuroprotection in tauopathies | |
| Program: | VEGA |
| Project leader: | Mgr. Majerová Petra, PhD. |
| Duration: | 1.1.2018 – 31.12.2020 |
| Vplyv patologického Tau proteínu na neuronálnu diferenciáciu a mitochondriálny metabolizmus | |
| Effect of pathological Tau protein on neuronal differentiation and mitochondrial metabolism | |
| Program: | VEGA |
| Project leader: | MVDr. Fialová Ľubica, PhD. |
| Duration: | 1.1.2018 – 31.12.2020 |
| Využitie zvieracích modelov pre tauopátie na identifikáciu molekulárnych dráh podieľajúcich sa na etiológii neurofibrilárnej degenerácie | |
| Use of animal models for tauopathies for identification of molecular pathways involved in the etiology of neurofibrillary degeneration | |
| Program: | VEGA |
| Project leader: | Ing. Hanes Jozef, DrSc. |
| Duration: | 1.1.2018 – 31.12.2020 |
| TAUPET – Vývoj nových neurozobrazovacích prístupov na predklinickú diagnostiku tauopatií využívajúcich transportné peptidy pre tau-špecifické nanoprotilátky | |
| Development of new neuro-imaging approaches for preclinical diagnosis of tauopathies using transport peptides for tau specific nanobodies | |
| Program: | Other projects |
| Project leader: | PharmDr. Kováč Andrej, PhD. |
| Duration: | 1.12.2018 – 31.12.2020 |
| Zmeny v hladine cirkulujúcich miRNA u hráčov ľadového hokeja po úrazoch hlavy: potenciálny marker poškodenia mozgu | |
| Changes in plasmatic miRNA level in ice-hockey players after the head injury: potential marker of traumatic brain injury | |
| Program: | VEGA |
| Project leader: | prof. RNDr. Kontseková Eva, DrSc. |
| Duration: | 1.1.2018 – 31.12.2020 |